Janet Julie Maguire, BSc (Bristol), PhD (London). College Lecturer in Pharmacology.
I supervise second year Medical and Veterinary Science Tripos (MVST) and Natural Sciences Tripos (NST) students in pharmacology; the Mechanisms of Drug Action (MODA) papers for medics and vets, and the 1B Pharmacology papers for NST students. The aim of my supervisions is to go beyond the information that is given in lectures and practical classes and to teach students how to apply this knowledge to the design and interpretation of pharmacological experiments. Supervisions cover all aspects of basic pharmacological analysis. The skills that are taught are essential for the thorough understanding of pharmacological concepts and so we teach all aspects of pharmacological analysis and data interpretation. Supervisions are interactive and designed to help the student develop academic and transferable skills. The material covered includes working through past practical paper, multiple choice, short answer and essay questions. Example classes on all aspects of the MODA/Pharmacology examinations are given each term. Feedback is given on all of the work. After supervisions materials and model answers are made available on our Pharmacology Moodle site for the students to use to re-enforce learning and for exam revision.
The research interests of my group encompass the human pharmacology of established and novel G-protein coupled receptors (GPCRs) in health and disease. We have an ongoing interest in the important cardiovascular peptide endothelin but research is currently focused on the apelin receptor and its role in pulmonary arterial hypertension. In particular I use human in vitro tissue bioassays to bridge basic and experimental medicine research. I am particularly interested in the development and pharmacology of biased apelin agonists for treatment of pulmonary arterial hypertension.
I am a Senior Research Associate in the Division of Experimental Medicine and Immunotherapeutics, within the Department of Medicine at Addenbrooke's. I am a member of the TMAT (Translational Medicine and Therapeutics) MPhil teaching committee, and I also lecture on clinical pharmacology and supervise laboratory based projects for this course. I am a principal investigator for 4-year Wellcome Trust/MRC PhD programmes and I supervise first year PhD rotation projects and subsequent PhD projects of students enrolled in the Wellcome Trust/MRC and BHF 4-year programmes in Cardiovascular Medicine. I also supervise research projects for Part II Pharmacology students at Addenbrooke's, and I currently have three PhD students.
- Official Fellow