Dr Janet Maguire, BSc (Bristol), MA (Cambridge), PhD (London). FBPharmacolS. John Eatwell Fellow in Medicine. Director of Studies Preclinical Medicine and Veterinary Medicine.
I am the Director of Studies for preclinical medicine and veterinary medicine students. I supervise second year Medical Sciences Tripos (MedST) and Veterinary Sciences Tripos (VST) students for the Mechanisms of Drug Action (MODA) course. The aim of my supervisions is to go beyond the information provided in lectures and practical classes and to teach students how to apply this knowledge to the design and interpretation of pharmacological experiments. Supervisions cover all aspects of basic pharmacological analysis, are interactive and designed to help students develop academic and transferable skills.
My research areas encompass the human pharmacology of established and novel G protein-coupled receptors (GPCRs) in health and disease. The group has an ongoing interest in the important cardiovascular peptide endothelin and the repurposing of existing drugs that target endothelin receptors for use in new therapeutic areas. A second major current interest is the apelin receptor and its endogenous peptides apelin and elabela. With collaborators we are exploring the therapeutic potential of novel, biased small molecule agonists in pulmonary arterial hypertension and of peptide antagonists in glioblastoma – both areas of unmet clinical need. I have published over 120 papers and am a Highly Cited Researcher (2019, 2020). H-Index 50. I am a Fellow of the British Pharmacological Scoiety and a contributor to the British Journal of Pharmacology ‘Concise Guide to Pharmacology’.
I am currently a visiting scientist with the Davenport Group in the Division of Experimental Medicine and Immunotherapeutics, Department of Medicine, based on the Biomedical Campus.
- Official Fellow
- John Eatwell Fellow in Medicine
- Director of Studies Preclinical Medicine and Veterinary Medicine
