Recent Publications

Listed below are some of our more recent papers. Other publications from the Bacterial Infection Group at the Department of Clinical Veterinary Medicine can be found at the following link Veterinary School Home page

Tötemeyer et al., (2006). Interferon-gamma enhances production of nitric oxide from macrophages via a mechanism that depends on NOD-2.  J. Immunol. 176, 4804-10

Bryant, et al., (2007) The cellular Toll-like receptor 4 antagonist E5531 can act as an agonist in horse whole blood.  Vet. Immunol. Immunopathol.122, 222-229

Cook et al., (2007)  Salmonella-induced SipB-independent cell death requires TLR4 signalling via the adapter proteins Tram and Trif.  Immunology122, 222-9

Núñez Miguel, et al., (2007) A Dimer of the Toll-Like Receptor 4 Cytoplasmic Domain Provides a Specific Scaffold for the Recruitment of Signalling Adaptor Proteins.  PLoS One 2, e788.


Cellular Biology of Infection Research at the Department of Clinical Veterinary Medicine

Research Outline

The aims of our research are to determine how mammals respond to bacterial infection and use this data to investigate potential new therapeutic strategies for man and animals. Our research work focusses on how cells such as macrophages detect bacteria and how the cell responds to them. Bacterial and bacterial wall componants are detected by Pattern Recognition Receptors such as the Toll-like and Nod receptors which then signal the presence of the microorganism to the cell. We are studing how the Pattern Recognition Receptors respond in different mammals to the same bacterium, whether Pattern Recognition Receptors function changes during infection and how bacteria modify Pattern Recognition Receptors function. Our work has recently expanded to consider investigate the dynamic interaction of salmonella with macrophages. This work is based on appliaction of mathematical models to salmonella-macrophage interactions and manipulation of bacteria using optical tweezers.

Current members of this research group include Clare Bryant, John, Wright, Bin Wei, Heather Brookes, Alicia Murcia, Suzanne Talbot.

The Bryant research group collaborates closely with Nick Gay (Biochemistry), Julia Gog (DAMTP), Ray Goldstein (DAMPT), Pietro Cicuta (Physics) and Duncan Maskell (Veterinary Medicine) in the University of Cambridge.

 

Macrophages infected with Salmonella enterica erovar Typhimurium (green and red particles).

 

 

Further information on our Graduate Research program can be found at Research at the Cambridge Veterinary School or e-mail the Research Secretary for enquiries

 

 

Our research work is generously supported by the Wellcome Trust, BBSRC and the HBLB